Here is a team-by-team listing of each school's high school football schedule entering the 2021 fall sports season. Games are subject to change:
Kickapoo
- Week 1 — @ Camdenton
- Week 2 — Lebanon
- Week 3 — @ Waynesville
- Week 4 — Parkview
- Week 5 — @ West Plains
- Week 6 — Rolla
- Week 7 — Glendale
- Week 8 — Bolivar
- Week 9 — @ Hillcrest
Glendale
- Week 1 — @ West Plains
- Week 2 — @ Rolla
- Week 3 — Hillcrest
- Week 4 — @ Bolivar
- Week 5 — Lebanon
- Week 6 — @ Parkview
- Week 7 — @ Kickapoo
- Week 8 — Camdenton
- Week 9 — Waynesville
Hillcrest
- Week 1 — @ Lebanon
- Week 2 — West Plains
- Week 3 — @ Glendale
- Week 4 — @ Rolla
- Week 5 — Waynesville
- Week 6 — @ Camdenton
- Week 7 — Bolivar
- Week 8 — @ Parkview
- Week 9 — Kickapoo
Parkview
- Week 1 — @ Waynesville
- Week 2 — @ Bolivar
- Week 3 — Camdenton
- Week 4 — @ Kickapoo
- Week 5 — Rolla
- Week 6 — Glendale
- Week 7 — @ West Plains
- Week 8 — Hillcrest
- Week 9 — @ Lebanon
Central
- Week 1 — Eldon
- Week 2 — Skyline
- Week 3 — Agape
- Week 4 — @ Marionville
- Week 5 — @ Sarcoxie
- Week 6 — Lighthouse Christian
- Week 7 — Missouri Military
- Week 8 — Buffalo
- Week 9 — Forsyth
Catholic
- Week 1 — @ Lamar
- Week 2 — McDonald County
- Week 3 — @ Marshfield
- Week 4 — Reeds Spring
- Week 5 — @ Aurora
- Week 6 — Logan-Rogersville
- Week 7 — @ Mount Vernon
- Week 8 — @ Monett
- Week 9 — Hollister
Nixa
- Week 1 — Branson
- Week 2 — @ Joplin
- Week 3 — Willard
- Week 4 — @ Republic
- Week 5 — @ Neosho
- Week 6 — Ozark
- Week 7 — Webb City
- Week 8 — @ Carl Junction
- Week 9 — Carthage
Ozark
- Week 1 — Carthage
- Week 2 — @ Branson
- Week 3 — Joplin
- Week 4 — @ Willard
- Week 5 — Republic
- Week 6 — @ Nixa
- Week 7 — Neosho
- Week 8 — @ Webb City
- Week 9 — Carl Junction
Logan-Rogersville
- Week 1 — @ Nevada
- Week 2 — Seneca
- Week 3 — @ Aurora
- Week 4 — @ Cassville
- Week 5 — Mount Vernon
- Week 6 — @ Catholic
- Week 7 — Hollister
- Week 8 — @ Marshfield
- Week 9 — Reeds Spring
Strafford
- Week 1 — Mountain View-Liberty
- Week 2 — @ Ava
- Week 3 — @ Miller
- Week 4 — @ Clever
- Week 5 — North Callaway
- Week 6 — @ Fair Grove
- Week 7 — Forsyth
- Week 8 — @ Stockton
- Week 9 — Skyline
Fair Grove
- Week 1 — Mountain Grove
- Week 2 — @ Mountain View-Liberty
- Week 3 — @ Skyline
- Week 4 — Forsyth
- Week 5 — @ Stockton
- Week 6 — Strafford
- Week 7 — @ Buffalo
- Week 8 — Clever
- Week 9 — El Dorado Springs
Republic
- Week 1 — Neosho
- Week 2 — @ Willard
- Week 3 — @ Webb City
- Week 4 — Nixa
- Week 5 — @ Ozark
- Week 6 — Joplin
- Week 7 — Carl Junction
- Week 8 — @ Carthage
- Week 9 — Branson
Willard
- Week 1 — @ Carl Junction
- Week 2 — Republic
- Week 3 — @ Nixa
- Week 4 — Ozark
- Week 5 — @ Joplin
- Week 6 — @ Carthage
- Week 7 — Branson
- Week 8 — @ Neosho
- Week 9 — Webb City
Ash Grove
- Week 1 — Diamond
- Week 2 — Cabool
- Week 3 — @ Stockton
- Week 4 — @ Pierce City
- Week 5 — Miller
- Week 6 — Agape
- Week 7 — @ Clever
- Week 8 — @ Marionville
- Week 9 — Sarcoxie
Bolivar
- Week 1 — Rolla
- Week 2 — Parkview
- Week 3 — @ Lebanon
- Week 4 — Glendale
- Week 5 — Camdenton
- Week 6 — @ Waynesville
- Week 7 — @ Hillcrest
- Week 8 — @ Kickapoo
- Week 9 — West Plains
Lebanon
- Week 1 — Hillcrest
- Week 2 — @ Kickapoo
- Week 3 — Bolivar
- Week 4 — @ Waynesville
- Week 5 — @ Glendale
- Week 6 — West Plains
- Week 7 — Camdenton
- Week 8 — @ Rolla
- Week 9 — @ Glendale
Waynesville
- Week 1 — Parkview
- Week 2 — @ Camdenton
- Week 3 — Kickapoo
- Week 4 — Lebanon
- Week 5 — @ Hillcrest
- Week 6 — Bolivar
- Week 7 — @ Rolla
- Week 8 — West Plains
- Week 9 — @ Glendale
Camdenton
- Week 1 — Kickapoo
- Week 2 — Waynesville
- Week 3 — @ Parkview
- Week 4 — West Plains
- Week 5 — @ Bolivar
- Week 6 — Hillcrest
- Week 7 — @ Lebanon
- Week 8 — @ Glendale
- Week 9 — Rolla
West Plains
- Week 1 — Glendale
- Week 2 — @ Hillcrest
- Week 3 — Rolla
- Week 4 — @ Camdenton
- Week 5 — Kickapoo
- Week 6 — @ Lebanon
- Week 7 — Parkview
- Week 8 — @ Waynesville
- Week 9 — @ Bolivar
Rolla
- Week 1 — @ Bolivar
- Week 2 — Glendale
- Week 3 — @ West Plains
- Week 4 — Hillcrest
- Week 5 — @ Parkview
- Week 6 — @ Kickapoo
- Week 7 — Waynesville
- Week 8 — Lebanon
- Week 9 — @ Camdenton
Marshfield
- Week 1 — @ Seneca
- Week 2 — Cassville
- Week 3 — Catholic
- Week 4 — @ Hollister
- Week 5 — @ East Newton
- Week 6 — Reeds Spring
- Week 7 — @ Aurora
- Week 8 — Logan-Rogersville
- Week 9 — @ Mount Vernon
Mount Vernon
- Week 1 — @ Cassville
- Week 2 — East Newton
- Week 3 — @ Reeds Spring
- Week 4 — Aurora
- Week 5 — @ Logan-Rogersville
- Week 6 — @ Lamar
- Week 7 — Catholic
- Week 8 — @ Hollister
- Week 9 — Marshfield
Reeds Spring
- Week 1 — @ East Newton
- Week 2 — Lamar
- Week 3 — Mount Vernon
- Week 4 — @ Catholic
- Week 5 — Hollister
- Week 6 — @ Marshfield
- Week 7 — @ McDonald County
- Week 8 — Aurora
- Week 9 — @ Logan-Rogersville
Branson
- Week 1 — @ Nixa
- Week 2 — Ozark
- Week 3 — @ Carl Junction
- Week 4 — Neosho
- Week 5 — Carthage
- Week 6 — @ Webb City
- Week 7 — @ Willard
- Week 8 — Joplin
- Week 9 — @ Republic
Hollister
- Week 1 — @ Monett
- Week 2 — Nevada
- Week 3 — @ Seneca
- Week 4 — Marshfield
- Week 5 — @ Reeds Spring
- Week 6 — Aurora
- Week 7 — @ Logan-Rogersville
- Week 8 — Mount Vernon
- Week 9 — @ Catholic
Mountain Grove
- Week 1 — @ Fair Grove
- Week 2 — Caruthersville
- Week 3 — Ava
- Week 4 — @ Willow Springs
- Week 5 — Cabool
- Week 6 — Mountain View-Liberty
- Week 7 — @ Salem
- Week 8 — @ Houston
- Week 9 — Thayer
Clever
- Week 1 — @ Willow Springs
- Week 2 — El Dorado Springs
- Week 3 — @ Forsyth
- Week 4 — Strafford
- Week 5 — @ Pierce City
- Week 6 — @ Skyline
- Week 7 — Ash Grove
- Week 8 — @ Fair Grove
- Week 9 — Agape
Marionville
- Week 1 — Stockton
- Week 2 — Willow Springs
- Week 3 — vs.