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In a tied game with the length of the court to go and 1.6 seconds remaining, Southern Illinois' Marcus Domask caught a deep ball and put it up right before the buzzer to break the Bears' hearts.
Missouri State (11-14, 5-7) fell to Southern Illinois (15-10, 9-3) 68-66 after a wild turn of events in the final seconds of Saturday night's game in Carbondale, Illinois.
The first half was a game of runs after the Bears looked to be in control when they took a 10-point lead midway through the first half.