(Photo: Andrew Jansen/News-Leader)
Evangel only played Missouri State three times before Friday night's game at JQH Arena and lost all three.
The Crusaders' first win over the Bears didn't come in the two schools' first meeting since 1985.
Missouri State (5-2) defeated Evangel (1-7) 80-48.
Eleven different Bears saw the court and scored during the team's blowout victory.
Jarred Dixon led the team with 13 points in his first start of the season.