The Kansas City Chiefs get reigning NFL MVP Patrick Mahomes back after a shorter-than-expected absence.
The Detroit Lions are without their quarterback, Matthew Stafford, for the first time in nearly a decade.
Mahomes was to start Sunday for the Chiefs at the Tennessee Titans, just over two weeks after he dislocated his kneecap.
There initially was concern that the quarterback could be sidelined for months. But it turned out there was no structural damage to the knee, and Mahomes never missed a practice.
He missed two games, with Matt Moore starting in his place.
Kansas City made running back LeSean McCoy a healthy scratch after he started six games this season, including the past four.