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Liriano returns to Target Field for just the fourth time as an opposing starter, and the first since he was a Pirate in 2015. But he’s familiar with the Twins, having pitched five innings of three-run ball against them in Detroit in his last start.

Santana has struggled to regain his velocity since coming back from finger surgery. He's coming off a tough outing against the Tigers, allowing five runs over six innings in a loss.