Southampton top scorer Charlie Austin is out after suffering a shoulder injury against Hapoel Beer Sheva.
Dusan Tadic returned from injury as a substitute in that match, while Jay Rodriguez and Sofiane Boufal have recovered from slight injuries.
Middlesbrough trio Gaston Ramirez, Alvaro Negredo and Jordan Rhodes are all injury doubts after missing training on Friday.
George Friend is continuing to build up his fitness after a knee problem.
MOTD COMMENTATOR'S NOTES
John Roder: "Middlesbrough travel south in the hope of making it a thoroughly miserable week for Southampton following their defeat at Crystal Palace last weekend and exit from the Europa League after the draw with Hapoel Beer Sheva on Thursday.