These two are on very different trajectories heading into their game at Fratton Park.
Middlesbrough remain unbeaten and head the table by two points while Portsmouth have taken only two points from their past four games.
This will be only the third league meeting between the sides in 13 years with Pompey taking four points from last season's two games.
Portsmouth have lost just one of their past eight league games against Middlesbrough (W2 D5), a 3-1 defeat in March 2012.
Middlesbrough have won just two of their past 13 away league games against Portsmouth (D4 L7).