ESPN.com · Sep 19, 2025
NFL Week 3 picks, predictions, schedule, odds, fantasy tips
The Week 3 NFL schedule for the 2025 season brings some intriguing matchups.
There are two battles between undefeated teams, with the Rams visiting the Eagles and the Cardinals facing the 49ers. Injuries have affected a few top QBs. The Bengals' Joe Burrow (toe), the Vikings' J.J. McCarthy (ankle) and the Jets' Justin Fields (concussion) are ruled out, and the 49ers' Brock Purdy (toe, shoulder) and the Commanders' Jayden Daniels (knee) are listed as questionable. With that, their notable backups are looking to make their mark. On Sunday night, the Chiefs look to dig themselves out of their first 0-2 start with Patrick Mahomes against the Giants.