The second-to-last home game for Michigan football in the 2025 season will be Saturday night against Purdue.
The Wolverines have a bye week, and two consecutive road games (Northwestern and Maryland) before hosting Ohio State to end the season.
The Wolverines are a 21-point favorite. Purdue hasn't won a Big Ten game yet. Purdue only has one win against an FBS team this season, although they were close in a 27-24 loss to Rutgers last week.
For Michigan, every game is a must-win if they want to make the College Football Playoff.