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NFL Week 5 Odds: Best Picks to Bet on Sunday's Schedule

The 2023 NFL season is in full swing, and Sunday's Week 5 slate features 12 solid matchups with action kicking off at 9:30 a.m. ET in London between the Jacksonville Jaguars and Buffalo Bills.

Of the 24 teams in action on Sunday, only two of them remain unbeaten—the Philadelphia Eagles and San Francisco 49ers. Both teams will be looking to improve to 5-0, though they'll each face some pretty difficult opponents.

The Eagles are slated for a meeting with Matthew Stafford and the Los Angeles Rams, which are expecting star wide receiver Cooper Kupp to return to the lineup, and the 49ers will take on Dak Prescott and the Dallas Cowboys.