4:05 p.m. ET | Fox
Matchup rating: 52.3 | Spread: SF -9 (49.5)
What to watch for: How will the 49ers bounce back after a disappointing loss last week? The Niners have lost both of their home games, and though last week's loss to the Eagles could be explained by a combination of injuries and a hangover from a long stay out East, they should have that out of their system and could be welcoming back more key pieces. The Dolphins, meanwhile, have to make one of the league's longest trips for this one.