Name: Southern Illinois University Edwardsville
Wait, no hyphen? Nope.
Location: Edwardsville, Illinois, duh
You’re being mean: Yeah, probably. Ostensibly, Edwardsville is a suburb of Saint Louis, even though it’s in a different state and the campus is located about 20 miles away from the Gateway Arch. If you look at Google Maps, though, you can draw a (mostly) straight line from Saint Louis proper to Edwardsville without leaving the gray urban area coloration.
Isn’t there a regular SIU? Yes, in Carbondale, which is about a two hour drive southeast from Edwardsville.