The boss has made just that one change to face Barça from the side beaten in the Reds' last outing, against Wolves at Molineux in the Premier League.
Rashford, who was injured and missed the defeat in the Midlands, is back in the forward line alongside Romelu Lukaku.
The only player from the Molineux XI who drops out is Jesse Lingard, who has to be content with a place on the bench against the Spanish champions.
Solskjaer's selection is also another huge vote of confidence for United Academy product Scott McTominay who plays his second major Champions League match, having featured in the astonishing 3-1 away win against Paris St Germain in the second leg of our last-16 tie.