A place in the semi-finals of Europe's elite competition is at stake for Ole Gunnar Solskjaer's side if we can navigate our way past the La Liga leaders.
After securing a place in the quarter-finals with an outstanding away-goals victory over Paris Saint-Germain that saw the Reds fight back to win 3-1 at the Parc des Princes, United will be looking to gain the advantage in the first leg of the tie before travelling to the Nou Camp for the second leg on 16 April.
Here’s everything you need to know ahead of Wednesday's anticipated showdown...
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