The Gunners currently hold that post ahead of the 12:30 BST kick-off at the Emirates Stadium, but United are just a point and a place behind in third, so leapfrogging our hosts is possible with a win.
Both clubs are already assured of a top-three spot and, with it, a place in next term's UEFA Women's Champions League but can secure a later entry into the 2025/26 European competition this weekend.
That's because the side that ends the WSL season in second will begin at the League Path's third qualifying round, as a pose to starting in the second qualifying round as the team that comes third.