The Reds open the month with a mouthwatering clash against reigning Barclays WSL champions Chelsea, at Leigh Sports Village.
That game has been selected for coverage on BBC Three and is set to kick off at 19:30 BST on Friday 3 October.
This slot is, however, subject to the progress of Leigh Leopards in the Super League play-offs.
The Leopards – who also count LSV as home – have qualified for the next stage of rugby league’s top tournament, but their exact schedule is yet to be confirmed.
Marc Skinner’s side will be looking for a first-ever WSL victory over the Blues, who have lifted the trophy at the end of each of our six seasons in the competition.