While Marcus Rashford and Cristiano Ronaldo are available for selection again after minor injuries, with the latter starting up front, Edinson Cavani, Luke Shaw and Jadon Sancho are all unavailable.
Speaking to club media at the Brentford Community Stadium pre-match, Rangnick explained that Cavani and Shaw had to pull out following a couple of small injury problems.
“Edinson had to drop out after training yesterday,” Rangnick told MUTV’s Stewart Gardner.
“He had a muscular problem, so for me, it was logical. I’m happy to have Cristiano back in the team.
“Luke, unfortunately, also had to pull out after yesterday's training.