It runs very deep, some would argue originating from the War of the Roses and the animosity between Lancashire and Yorkshire, and any excursion across the Pennines to Elland Road is one done recognising the challenge of playing on enemy territory.
Ever since Leeds came to Bank Street and won 3-0 in 1906, there has been some spice about the fixture and it will be a hostile environment facing Ruben Amorim's men for the 12:30 GMT kick-off this weekend.
United (even saying that will anger Leeds supporters) are unbeaten in our last 25 league outing against promoted sides, winning 22 of those games, since a defeat at Watford proved to be Ole Gunnar Solskjaer's final match in charge.