The homegrown Academy graduate has been given the nod to make his third appearance of the season with David De Gea, named Premier League Player of the Month on Friday, not in the matchday squad.
It is another chance for Henderson to impress, under the lights at Old Trafford, in the Emirates FA Cup fourth-round encounter.
"Again, with him, we have a fantastic goalkeeper," Ralf told MUTV's Stewart Gardner before the game.
"His training performances, since I arrived, have been outstanding and that's why I have decided to give him a game tonight in front of a sold-out Old Trafford stadium.