The forward was a notable absentee when the matchday squad was announced at 14:00 GMT, one hour before kick-off at Vicarage Road, having been a regular starter so far this season.
In his pre-match interview at the stadium, United manager Ole Gunnar Solskjaer revealed: "Mason has got COVID unfortunately. He's tested positive, so we'll wait for him to get back."
Greenwood's fellow England internationals Jadon Sancho and Marcus Rashford are both in Solskjaer's line-up, joining Portuguese pair Bruno Fernandes and Cristiano Ronaldo in the front four.
More to follow...
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