Both players also missed the opening game of Tour 2019, the 2-0 victory against Perth Glory, but it was hoped they would be back in contention to feature against the Yorkshire outfit at the Optus Stadium.
However, De Gea was not feeling well ahead of the match and Lukaku picked up a knock in training, joining Lee Grant and Luke Shaw on the sidelines.
“David just fell ill today so he didn’t feel right,” Ole explained to MUTV, who are showing all the Tour 2019 games live. “We’ll wait until the Inter Milan game [on Saturday] for him.