The starting XI is particularly hard to guess with several fresh injury concerns since the weekend: Harry Maguire is definitely out, while Raphael Varane and Bruno Fernandes are doubts.
Meanwhile, Aaron Wan-Bissaka, Lisandro Martinez, Tyrell Malacia, Luke Shaw, Mason Mount, Rasmus Hojlund and Anthony Martial are all still sidelined.
Remember, you have until 18:15 GMT to register your line-up, and then until kick-off at 19:45 GMT to predict the first scorer, correct score and Man of the Match.
Before you do, read what our pundits are saying…
WES BROWN
The Academy graduate and Treble winner expects Victor Lindelof to move from left-back to centre-back, with Sofyan Amrabat filling in on the flank…
Line-up: Onana; Dalot, Lindelof, Evans, Amrabat; Mainoo, Eriksen, McTominay; Antony, Rashford, Garnacho.