The Reds kick off our campaign with Sunday's home match with Brighton & Hove Albion (14:00 BST kick-off), in Erik ten Hag's first competitive fixture in charge.
We know the dugouts have been switched at Old Trafford, meaning Erik and his staff will be closer to the Stretford End and tunnel, but what other things will be different about the upcoming season?
The Premier League has announced some things to look out for:
FIVE SUBSTITUTES
Managers can now make five substitutions after this was raised from three, with agreement reached on the subject at a summer meeting between the clubs.