In addition to this momentous match, the young Reds also have the last match of the Under-18 Premier League season to play on Saturday, but the senior men's and women's teams do not have any fixtures to contend with.
There will also be a number of anniversaries which we will be marking across the week.
Here’s how the next seven days look at United…
MONDAY
With two days to go until the FA Youth Cup final, our build-up will include a special edition of the UTD Podcast, featuring Nick Cox - Head of Manchester United Academy.