The Spaniard has a long and dramatic history of managing teams against United, dating back to his spell with the Blues' neighbours, Liverpool.
Benitez took the reins at Anfield in 2004, and was one of Sir Alex Ferguson's bete noires during a six-year spell on Merseyside. He went on to manage Chelsea and Newcastle, and has now been tasked with leading Everton forward.
The two-time La Liga winner (with Valencia) is sure to get a frosty reception on Saturday due to his former association with our great rivals, but Benitez has enjoyed some memorable moments at the Theatre of Dreams during a long career.