The match, which kicks off at 15:00 GMT at Selhurst Park, is being broadcast live on MUTV, and you don’t want to miss it.
The Reds lifted the trophy last season, becoming the first United side to do it since 2011, and Travis Binnion’s team are looking to retain it this term.
Find out how you can follow all of the action on MUTV, ManUtd.com and the United App…
HOW CAN YOU FOLLOW THE GAME?
Crystal Palace U18s v United U18s will be broadcast live on MUTV, which can be accessed via the United App on the iOS App Store or Google Play Store, on ManUtd.