Valencia, who made 339 appearances for the club in a career that spanned a decade, also captained the side in his final season.
Known for his powerful wing play and blistering strikes, the Ecuadorian became a fan favourite during his time in Manchester and is looking forward to being reunited with the Old Trafford faithful.
“My time at Manchester United gave me some of the fondest memories of my career,” Antonio said. “I was involved in great teams that won many trophies and it will be fantastic to see some of my former team-mates again for this special match.