Manchester United visit the Mestalla with an outside chance of usurping Juventus in top spot in Group H.
Jose Mourinho's side have already sewn up qualification for the Champions League knockout stages and are expected to field a weakened team.
The hosts have nothing to play for so will only have pride on the line. Paul Pogba is set to start for United as Mourinho rests plenty of key performers with Sunday's derby against Liverpool in mind.
United need Young Boys to do them a favour and beat Juventus for them to stand a chance at going through on top of the log.