Ruben Amorim's side will feature in the only top-flight game on Boxing Day, facing Newcastle United at Old Trafford, with the festive showdown kicking off at 20:00 GMT.
Our final outing of 2025 is also at home, with Wolverhampton Wanderers providing the opposition on Tuesday 30 December.
The kick-off time has been pushed back to 20:15 GMT and, like the Newcastle encounter, Sky Sports will be showing it live in the UK.
The Reds begin 2026 with a cracker, the eagerly anticipated trip across the Pennines to face Leeds United at Elland Road.