The fixture at the MetLife Stadium in New Jersey takes place on Saturday night in the United States, kicking off at 00:00 BST on Sunday morning in the UK.
It is live on MUTV for all subscribers, except for those based in the US, with NBC Sports having the rights.
Ruben Amorim's men trained in front of the press at Chicago and it was clear Andre Onana, Lisandro Martinez and Joshua Zirkzee were away from the main group, working on their individual programmes.
Centre-back Harry Maguire has now joined the squad and could be available to feature against the Hammers after training with the squad.