The Reds know a victory at Old Trafford will strengthen our Champions League aspirations, as we hunt down Chelsea and Leicester City in the final two remaining top-four places.
As for the Saints, they will be looking to continue their impressive run of results since Project Restart, which has included victories over Norwich City, Watford and Manchester City.
Ahead of the clash at the Theatre of Dreams, here’s everything you need to know…
WHICH TV CHANNEL IS IT ON?
Monday's Premier League match will be broadcast live in the UK, on Sky Sports Premier League and Sky Sports Main Event, with kick-off set for 20:00 BST.