In our matchday programme, United Review, we celebrated this remarkable milestone by flicking back through history to recall some of the unforgettable moments at the iconic arena - with many more to come in the future.
Below, you can read the full feature from the Luton programme, which you can still purchase online...
#1 | OPENING DAY
UNITED 3 LIVERPOOL 4 | 19 FEBRUARY 1910
Though Old Trafford’s maiden fixture hardly unfurled in the fashion United had hoped for, with leads repeatedly squandered in a seven-goal thriller against the visiting Merseysiders, the stadium’s mere opening represented a major landmark in club history.