But as the fixture's storied past tells us, there are duels to be won all over the pitch and individual contributions can prove telling.
The likes of Dimitar Berbatov, Rio Ferdinand and Diego Forlan have all etched their names into this rivalry’s folklore with their heroic impacts deciding contests at Old Trafford or Anfield, and our United Predictions game has been asking fans to guess who could be the Man of the Match this time around.
Play the game now in the United App and you can also predict Erik ten Hag’s starting line-up, the first goalscorer and the final score.