Kick-off at Brunton Park is scheduled for 19:30 BST but unfortunately the game will not be shown live on MUTV due to broadcasting rules.
The United App will provide team news and summaries at half-time and full-time, plus a gallery of match images. Video highlights will be available from tomorrow.
The Carlisle clash is the first of three fixtures for Mark Dempsey's side in Group G of the competition's northern section, all of which will be away from home and will kick off at 19:30 BST.
The Reds will return to Cumbria on Tuesday 4 October, when Barrow will be our hosts at The Dunes Hotel Stadium.