Interim manager Ralf Rangnick takes charge for the last time as the Reds seek the three points that would secure Europa League football next term, irrespective of West Ham United's result at Brighton & Hove Albion.
Palace surrendered a 2-0 lead at Everton on Thursday night but will want to go out on a positive note in front of their noisy Selhurst Park crowd, while United look forward to welcoming Erik ten Hag as our new boss.
There are a whole host of absentees, including Luke Shaw, Nemanja Matic, Cristiano Ronaldo, Jadon Sancho and Marcus Rashford.
It means a first start for promising youngster Hannibal, while Edinson Cavani leads the line.