Much-decorated pair Darren Fletcher and Michael Carrick are welcome introductions to the midfield and will make their debuts for the Legends side.
Meanwhile, former striker Andy Ritchie will take charge of the team - in the absence of Bryan Robson - and he will be assisted by Andy Cole.
The charity game, which raises vital funds for local communities, kicks off at 15:00 BST on Saturday.
The first leg of the Legends of the North clash with Liverpool was staged at Old Trafford in May, raising over £1.3million for Manchester United Foundation. It finished 3-1 to the Merseysiders, with Dimitar Berbatov scoring our goal.