Antony was absent from training at Carrington due to illness and therefore does not make the trip, along with four players who were spotted by the cameras at our base on Wednesday morning - Nathan Bishop, Zidane Iqbal, Kobbie Mainoo and Anthony Martial.
However, Marcel Sabitzer makes a welcome return to the fold, after missing our last two games, and Victor Lindelof is back after illness.
Casemiro is available as his four-match suspension only covers domestic fixtures.
Alejandro Garnacho has joined Christian Eriksen and Donny van de Beek on the sidelines due to injury.
UNITED'S SQUAD FOR REAL BETIS (A)
Goalkeepers: David De Gea, Tom Heaton, Jack Butland.