The clash at the LNER Stadium will kick off at 19:00 BST, with our Under-21s taking on senior opposition in the Vertu-sponsored competition.
Travis Binnion's side will also face Barnsley and Notts County, away from home, in Group D.
Meanwhile, the Reds have also been drawn in Group D of the Premier League International Cup.
This will mean games against Anderlecht, Athletic Club, Borussia Dortmund and Sporting.
These fixtures will be announced, along with the Premier League 2 programme, in due course.
PREMIER LEAGUE INTERNATIONAL CUP
Group A: Everton, Manchester City, Southampton, Wolves, Monaco, PSV Eindhoven, RB Leipzig, Real Madrid.