The 12:00 BST kick-off will take place at Leigh Sports Village and comes just days after the young Reds were narrowly defeated by Salford City in the Papa Johns Trophy.
Ahead of the match, find out how you can follow updates on the action...
Tuesday night's loss at Salford City held many positives for our Under-21s, with Shola Shoretire getting two goals and Omari Forson grabbing one himself. Kobbie Mainoo also played the full match, as he continues to work his way back from the injury he suffered in pre-season with our first team.
Unfortunately, due to Premier League matches - including United first team's 12:30 GMT kick-off against Fulham - taking place on Saturday, it will not be broadcast live on MUTV.