The amendments are being implemented as the European competitions restart, after coming into effect on 1 June.
It means the round-of-16 second leg at Old Trafford is affected, in addition to the temporary measure of five substitutions being permitted per side.
UEFA's chief refereeing officer Roberto Rosetti explained: “In general, with the Laws of the Game, there are just a few minor changes. The most important changes are about Law 14, on the penalty-kicks and Law 10 - determining the outcome of a match.”
The laws on penalties now state an offence by the goalkeeper is not penalised if the spot-kick misses the goal or rebounds from the goal (without a touch from the keeper) unless the offence clearly affected the taker.