Looking to follow up on our opening win in the competition against Athletic Club, at Old Trafford, it was Belgian opposition next up for Travis Binnion's side.
Despite taking the lead during the first 45 minutes through captain Jacob Devaney, Anderlecht found the net four times in the second half to put the result beyond any doubt.
Enzo Sternal, Terry Van De Ven, Yasin Ozcan and Samuel Ntanda all scored in the second period, on a disappointing evening at the Progress With Unity Stadium.
FIRST HALF
Papealiya N'Dao created the first real chance of the evening after just two minutes gone, shooting just wide to help earn Anderlecht an early corner.