The 23-year-old has also signed a new contract at Manchester United, lasting until June 2023 with the option of an additional year's extension.
It's a return to Villa Park for Tuanzebe who has already enjoyed two spells with the Midlands club, including in 2018/19 when he helped them achieve Championship play-off glory.
Having endured a difficult campaign last time out due to a couple of injuries, the highly rated centre-back will use this loan as a vital opportunity to assert himself and make an impression.
Tuanzebe has been with United from a very young age and has captained the club at every level, including the first team for a Carabao Cup game against Rochdale in September 2019, when he became the youngest man to wear the armband since Norman Whiteside.