Ole Gunnar Solskjaer suggested last week that Tuanzebe and Fosu-Mensah were likely to be available for an outing at this level.
Axel has been sidelined since playing in the Carabao Cup win over Colchester United on 18 December. Tim's last United appearance was the final match of the 2016/17 season, against Crystal Palace, but he has been out on loan to the Eagles and Fulham in previous campaigns.
Fosu-Mensah, who had a knee injury, initially made his comeback in the Under-23s' clash with Newcastle on 10 January but then suffered a small setback with a minor thigh problem.