Thursday's huge 20:00 BST kick-off presents the Reds with the opportunity to continue our unbeaten run in the competition, in the quest to earn a return trip to San Mames for the final on 21 May.
A side currently fourth in La Liga, with an impressive home record, stand in United's way but the good news is Matthijs de Ligt and Amad have both made the flight.
Whether the pair, who returned from injury lay-offs to participate in Wednesday's open training at Carrington, will be named in the actual matchday squad is yet to be confirmed.
A larger group has been selected as there is due to be a session locally on Friday morning, which will feature youngsters, including Chido Obi and Sekou Kone, who are not eligible to play in the Europa League.