There are a number of rule changes and innovations to keep an eye out for, starting with Sunday's 16:30 BST kick-off against Arsenal at Old Trafford.
Fans can also take advantage of a Pop-Up Pub at the ground for the opener and, of course, there are some fresh faces in the United squad after a busy summer of transfers, with the deadline not due until 1 September.
TIME-WASTING
A new eight-second rule has been introduced in an attempt to stop goalkeepers from hanging onto the ball for too long. The referee will determine when this starts and signal when it is close to being broken by counting down.