Sunday's 16:30 GMT kick-off presents an opportunity for Erik ten Hag's side to reach Wembley again, with the semi-finals of the competition staged at the national stadium.
However, Fulham represent tough opponents as they currently sit comfortably in ninth place in the Premier League table, having had a full week to prepare for the big game.
During his pre-match interview with club media at Carrington, the manager was asked to provide an update on two of the midweek absentees ahead of the cup contest.
Brazil winger Antony missed the 1-0 win over Real Betis due to illness and Anthony Martial was also not on the trip, despite returning to training recently.