The Reds take on Brighton & Hove Albion in a 14:00 BST kick-off at Old Trafford, looking to get off to the perfect start in the sunshine.
With Anthony Martial out injured, there was a question mark over who would start in attack, with Cristiano Ronaldo only having 45 minutes of pre-season action under his belt.
The boss has opted either to field Marcus Rashford up front or utilising Bruno Fernandes as a 'false nine', with Ronaldo starting on the bench.
Lisandro Martinez and Christian Eriksen make their competitive debuts for the Reds, with fellow new boy Tyrell Malacia among the substitutes.