The Reds travel to City's Etihad Stadium having won six of our last seven games in all competitions, with the latest outing being Wednesday's dramatic late Emirates FA Cup victory at Nottingham Forest.
Ten Hag has made two changes from the side which started at The City Ground, with Jonny Evans and Kobbie Mainoo replacing Sofyan Amrabat and Antony, who drop to the bench.
It remains to be seen how exactly the Reds line up to start the game, but Victor Lindelof could play at left-back, having deputised there recently.
While Mainoo will likely partner Casemiro in midfield, Scott McTominay has the ability to play in a more advanced role and Bruno Fernandes captains the side having played through the pain barrier in the East Midlands in midweek.