One of the Dutchman's changes was enforced, due to the absence of Victor Lindelof, who picked up a knock in our 2-1 victory over Chelsea.
Luke Shaw moves into central defence to partner Harry Maguire, while Sergio Reguilon starts at left-back
The second change is up front, where Anthony Martial replaces Rasmus Hojlund, with Alejandro Garnacho and Antony occupying the flanks.
"A second game in the week for Victor, he did very good. For Hojlund, he has played a lot of games and there are [still] many games to play as well," he told MUTV.
"But also we give Anthony Martial an opportunity, he played very good against Everton, a good performance against Newcastle.