The boss has made five alterations to the XI that lined up at the Nou Camp for our 2-2 draw with Barcelona on Thursday night.
Three of those are in the back four, as Diogo Dalot, Victor Lindelof and Lisandro Martinez all come in to join Luke Shaw in defence.
In midfield Marcel Sabitzer returns to start alongside Fred, while Alejandro Garnacho joins the attacking unit with Bruno Fernandes, Marcus Rashford and Wout Weghorst.
During his pre-match interviews, Ten Hag confirmed that Harry Maguire, who is absent from the squad, is out injured.
On today’s match, he added: “The first game is always the most important.